Multiple Novel Prostate Cancer Predisposition Loci Confirmed by an International Study: The PRACTICAL Consortium

Kote‐Jarai, Zsofia; F. Easton, Douglas; L. Stanford, Janet; A. Ostrander, Elaine; Schleutker, Johanna; A. Ingles, Sue; J. Schaid, Daniel; N. Thibodeau, Stephen; Dörk, Thilo; E. Neal, David; Cox, Angela; Maier, Christiane; Vogel, W.; Guy, Michelle; Muir, Kenneth; Lophatananon, Artitaya; Kedda, Mary-Anne; B. Spurdle, Amanda; K. Steginga, Suzanne; M. John, Esther; G. Giles, Graham; L. Hopper, John; O. Chappuis, Pierre; Hutter, Pierre; D. Foulkes, William; Hamel, Nancy; A. Salinas, Claudia; S. Koopmeiners, Joseph; M. Karyadi, Danielle; Johanneson, Bo; Wahlfors, Tiina; L.J. Tammela, Teuvo; C. Stern, Mariana; Corral, Román; K. McDonnell, Shannon; Schürmann, Peter; Meyer, Andreas; Kuefer, Rainer; Leongamornlert, Daniel; Tymrakiewicz, Malgorzata; Liu, Jo‐Fen; A. O’Mara, Tracy; A. Gardiner, Robert; F. Aitken, Joanne; D. Joshi, Amit; Severi, Gianluca; R. English, Dallas; C. Southey, Melissa; M. Edwards, Stephen; Amin Al Olama, Ali; A. Eeles, Rosalind

doi:10.1158/1055-9965.epi-08-0317

Public

Multiple Novel Prostate Cancer Predisposition Loci Confirmed by an International Study: The PRACTICAL Consortium

Published in Cancer Epidemiology Biomarkers & Prevention • Aug 1, 2008

Authors:

Zsofia Kote‐Jarai

Douglas F. Easton

Janet L. Stanford

Abstract

A recent genome-wide association study found that genetic variants on chromosomes 3, 6, 7, 10, 11, 19 and X were associated with prostate cancer risk. We evaluated the most significant single-nucleotide polymorphisms (SNP) in these loci using a worldwide consortium of 13 groups (PRACTICAL). Blood DN...

Subject

Single-nucleotide polymorphism

Prostate cancer

Odds ratio

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