A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes

V. Rostovtsev, Vsevolod; G. Green, Luke; V. Fokin, Valery; Barry Sharpless, K.

doi:10.1002/1521-3773(20020715)41:14<2596::aid-anie2596>3.0.co;2-4

Public

A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes

Published in Angewandte Chemie International Edition • Jul 15, 2002

Authors:

Vsevolod V. Rostovtsev

Luke G. Green

Valery V. Fokin

Abstract

By simply stirring in water, organic azides and terminal alkynes are readily and cleanly converted into 1,4-disubstituted 1,2,3-triazoles through a highly efficient and regioselective copper(I)-catalyzed process (see scheme for an example).

Subject

Regioselectivity

Cycloaddition

Terminal (telecommunication)

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