Selective Effect of 2′,6′-Dihydroxy-4′-Methoxychalcone Isolated from<i>Piper aduncum</i>on<i>Leishmania amazonensis</i>

Caio Torres-Santos, Eduardo; Lima Moreira, Davyson; Auxiliadora Coelho Kaplan, Maria; N. L. Meirelles, M.; Rossi‐Bergmann, Bartira

doi:10.1128/aac.43.5.1234

Public

Selective Effect of 2′,6′-Dihydroxy-4′-Methoxychalcone Isolated fromPiper aduncumonLeishmania amazonensis

Published in Antimicrobial Agents and Chemotherapy • May 1, 1999

Authors:

Eduardo Caio Torres-Santos

Davyson Lima Moreira

Maria Auxiliadora Coelho Kaplan

Abstract

2',6'-Dihydroxy-4'-methoxychalcone (DMC) was purified from the dichloromethane extract of Piper aduncum inflorescences. DMC showed significant activity in vitro against promastigotes and intracellular amastigotes of Leishmania amazonensis, with 50% effective doses of 0.5 and 24 micrograms/ml, respec...

Subject

Amastigote

Nitric oxide

Leishmania

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