Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice

Sugimoto, Hirokazu; Okada, Kosuke; Shoda, Junichi; Warabi, Eiji; Ishige, Kazunori; Ueda, Tetsuya; Taguchi, Keiko; Yanagawa, Toru; Nakahara, Akira; Hyodo, Ichinosuke; Ishii, Tetsuro; Yamamoto, Masayuki

doi:10.1152/ajpgi.00296.2009

Public

Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice

Published in American Journal of Physiology-Gastrointestinal and Liver Physiology • Nov 20, 2009

Authors:

Hirokazu Sugimoto

Kosuke Okada

Junichi Shoda

Abstract

Oxidative stress is a critical mediator in liver injury of steatohepatitis. The transcription factor Nrf2 serves as a cellular stress sensor and is a key regulator for induction of hepatic detoxification and antioxidative stress systems. The involvement of Nrf2 in defense against the development of ...

Subject

Steatohepatitis

Oxidative stress

Superoxide dismutase

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