Genome-wide hepatitis C virus amino acid covariance networks can predict response to antiviral therapy in humans

Aurora, Rajeev; J. Donlin, Maureen; A. Cannon, Nathan; E. Tavis, John

doi:10.1172/jci37085

Public

Genome-wide hepatitis C virus amino acid covariance networks can predict response to antiviral therapy in humans

Published in Journal of Clinical Investigation • Dec 22, 2008

Authors:

Rajeev Aurora

Maureen J. Donlin

Nathan A. Cannon

Abstract

Hepatitis C virus (HCV) is a common RNA virus that causes hepatitis and liver cancer. Infection is treated with IFN-alpha and ribavirin, but this expensive and physically demanding therapy fails in half of patients. The genomic sequences of independent HCV isolates differ by approximately 10%, but t...

Subject

Ribavirin

Hepatitis C virus

Virology

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