JAK mutations in high-risk childhood acute lymphoblastic leukemia

G. Mullighan, Charles; Zhang, Jinghui; C. Harvey, Richard; Racquel Collins-Underwood, J.; A. Schulman, Brenda; A. Phillips, Letha; K. Tasian, Sarah; L. Loh, Mignon; Su, Xiaoping; Liu, Wei; Devidas, Meenakshi; R. Atlas, Susan; Chen, I‐Ming; Clifford, Robert; S. Gerhard, Daniela; L. Carroll, William; H. Reaman, Gregory; A. Smith, Malcolm; R. Downing, James; P. Hunger, Stephen; L. Willman, Cheryl

doi:10.1073/pnas.0811761106

Public

JAK mutations in high-risk childhood acute lymphoblastic leukemia

Published in Proceedings of the National Academy of Sciences • May 22, 2009

Authors:

Charles G. Mullighan

Jinghui Zhang

Richard C. Harvey

Abstract

Pediatric acute lymphoblastic leukemia (ALL) is a heterogeneous disease consisting of distinct clinical and biological subtypes that are characterized by specific chromosomal abnormalities or gene mutations. Mutation of genes encoding tyrosine kinases is uncommon in ALL, with the exception of Philad...

Subject

Cancer research

Biology

Tyrosine kinase

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