Production of α1,3-Galactosyltransferase-Deficient Pigs

J. Phelps, Carol; Koike, Chihiro; Vaught, Todd; Boone, Jeremy; D. Wells, Kevin; Chen, Shu-Hung; Ball, Suyapa; Specht, Susan; A. Polejaeva, Irina; A. Monahan, Jeff; M. Jobst, Pete; B. Sharma, Sugandha; E. Lamborn, Ashley; S. Garst, Amy; Moore, Marilyn; J. Demetris, Anthony; A. Rudert, William; Bottino, Rita; Bertera, Suzanne; Trucco, Massimo; E. Starzl, Thomas; Dai, Yifan; Ayares, David

doi:10.1126/science.1078942

Public

Production of α1,3-Galactosyltransferase-Deficient Pigs

Published in Science • Jan 16, 2003

Authors:

Carol J. Phelps

Chihiro Koike

Todd Vaught

Abstract

The enzyme alpha1,3-galactosyltransferase (alpha1,3GT or GGTA1) synthesizes alpha1,3-galactose (alpha1,3Gal) epitopes (Galalpha1,3Galbeta1,4GlcNAc-R), which are the major xenoantigens causing hyperacute rejection in pig-to-human xenotransplantation. Complete removal of alpha1,3Gal from pig organs is...

Subject

Xenotransplantation

Gene

Point mutation

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