CRACM1 Is a Plasma Membrane Protein Essential for Store-Operated Ca <sup>2+</sup> Entry

Vig, Monika; Peinelt, Christine; Beck, Andreas; L. Koomoa, Dana; Rabah, Dania; Koblan‐Huberson, Murielle; Kraft, Stefan; Turner, Helen; Fleig, Andrea; Penner, Reinhold; Kinet, J.-P.

doi:10.1126/science.1127883

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CRACM1 Is a Plasma Membrane Protein Essential for Store-Operated Ca 2+ Entry

Published in Science • Apr 27, 2006

Authors:

Monika Vig

Christine Peinelt

Andreas Beck

Abstract

Store-operated Ca2+ entry is mediated by Ca2+ release-activated Ca2+ (CRAC) channels following Ca2+ release from intracellular stores. We performed a genome-wide RNA interference (RNAi) screen in Drosophila cells to identify proteins that inhibit store-operated Ca2+ influx. A secondary patch-clamp s...

Subject

Gene knockdown

RNA interference

Cell biology

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