Imeglimin Normalizes Glucose Tolerance and Insulin Sensitivity and Improves Mitochondrial Function in Liver of a High-Fat, High-Sucrose Diet Mice Model

Vial, Guillaume; Chauvin, Marie‐Agnès; Bendridi, Nadia; Durand, Annie; Meugnier, Emmanuelle; Madec, Anne‐Marie; Bernoud‐Hubac, Nathalie; Paı̈s de Barros, Jean-Paul; Fontaine, Éric; Acquaviva, Cécile; Hallakou‐Bozec, Sophie; Bolze, Sébastien; Vidal, Hubert; Rieusset, Jennifer

doi:10.2337/db14-1220

Public

Imeglimin Normalizes Glucose Tolerance and Insulin Sensitivity and Improves Mitochondrial Function in Liver of a High-Fat, High-Sucrose Diet Mice Model

Published in Diabetes • Dec 31, 2014

Authors:

Guillaume Vial

Marie‐Agnès Chauvin

Nadia Bendridi

Abstract

Imeglimin is the first in a new class of oral glucose-lowering agents currently in phase 2b development. Although imeglimin improves insulin sensitivity in humans, the molecular mechanisms are unknown. This study used a model of 16-week high-fat, high-sucrose diet (HFHSD) mice to characterize its an...

Subject

Internal medicine

Endocrinology

Insulin

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