A variance-stabilizing transformation for gene-expressionmicroarray data

Durbin, Blythe; Hardin, J.S.; M. Hawkins, Douglas; M. Rocke, David

doi:10.1093/bioinformatics/18.suppl_1.s105

Public

A variance-stabilizing transformation for gene-expressionmicroarray data

Published in Bioinformatics • Jul 1, 2002

Authors:

Blythe Durbin

J.S. Hardin

Douglas M. Hawkins

Abstract

MOTIVATION: Standard statistical techniques often assume that data are normally distributed, with constant variance not depending on the mean of the data. Data that violate these assumptions can often be brought in line with the assumptions by application of a transformation. Gene-expression microar...

Subject

Transformation (genetics)

Variance (accounting)

Data transformation

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