Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women

Abdool Karim, Quarraisha; S. Abdool Karim, Salim; Frohlich, Janet; Grobler, Anneke; Baxter, Cheryl; E. Mansoor, Leila; B. M. Kharsany, Ayesha; Sibeko, Sengeziwe; Mlisana, Koleka; Omar, Zaheen; N. Gengiah, Tanuja; Maarschalk, Silvia; Arulappan, Natasha; Mlotshwa, Mukelisiwe; Morris, Lynn; Taylor, Douglas; behalf of the CAPRISA 004 Trial Group, on

doi:10.1126/science.1193748

Public

Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women

Published in Science • Jul 20, 2010

Authors:

Quarraisha Abdool Karim

Salim S. Abdool Karim

Janet Frohlich

Abstract

The Centre for the AIDS Program of Research in South Africa (CAPRISA) 004 trial assessed the effectiveness and safety of a 1% vaginal gel formulation of tenofovir, a nucleotide reverse transcriptase inhibitor, for the prevention of HIV acquisition in women. A double-blind, randomized controlled tria...

Subject

Medicine

Microbicide

Placebo

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