Microglial CB2 cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity.

J, Palazuelos; T, Aguado; MR, Pazos; B, Julien; C, Carrasco; E, Resel; O, Sagredo; C, Benito; J, Romero; I, Azcoitia; J, Fernández-Ruiz; M, Guzmán; I, Galve-Roperh

doi:10.1093/brain/awp239

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Microglial CB2 cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity.

Shared by NobleBlocks on Oct 5, 2009 • 12:00 AM UTC

Authors:

Palazuelos J

Aguado T

Pazos MR

Abstract

Cannabinoid-derived drugs are promising agents for the development of novel neuroprotective strategies. Activation of neuronal CB(1) cannabinoid receptors attenuates excitotoxic glutamatergic neurotransmission, triggers prosurvival signalling pathways and palliates motor symptoms in animal models of...

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