Microglial CB2 cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity

Palazuelos, Javier; Aguado, Tania; Ruth Pazos, M.; Julien, Boris; Carrasco, Carolina; Resel, Eva; Sagredo, Onintza; Benito, Cristina; Romero, Julián; Azcoitia, Íñigo; Fernández‐Ruíz, Javier; Guzmán, Manuel; Galve‐Roperh, Ismael

doi:10.1093/brain/awp239

Public

Microglial CB2 cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity

Published in Brain • Oct 5, 2009

Authors:

Javier Palazuelos

Tania Aguado

M. Ruth Pazos

Abstract

Cannabinoid-derived drugs are promising agents for the development of novel neuroprotective strategies. Activation of neuronal CB(1) cannabinoid receptors attenuates excitotoxic glutamatergic neurotransmission, triggers prosurvival signalling pathways and palliates motor symptoms in animal models of...

Subject

Excitotoxicity

Neuroprotection

Quinolinic acid

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