3D cell culture and osteogenic differentiation of human bone marrow stromal cells plated onto jet-sprayed or electrospun micro-fiber scaffolds

Á. Brennan, Meadhbh; Renaud, Audrey; Gamblin, Anne-Laure; d’Arros, Cyril; Nédellec, Steven; Trichet, Valérie; Layrolle, Pierre

doi:10.1088/1748-6041/10/4/045019

Public

3D cell culture and osteogenic differentiation of human bone marrow stromal cells plated onto jet-sprayed or electrospun micro-fiber scaffolds

Published in Biomedical Materials • Aug 4, 2015

Authors:

Meadhbh Á. Brennan

Audrey Renaud

Anne-Laure Gamblin

Abstract

A major limitation of the 2D culture systems is that they fail to recapitulate the in vivo 3D cellular microenvironment whereby cell-cell and cell-extracellular matrix (ECM) interactions occur. In this paper, a biomaterial scaffold that mimics the structure of collagen fibers was produced by jet-spr...

Subject

Scaffold

Materials science

Mesenchymal stem cell

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