Impairment of starvation-induced and constitutive autophagy in
                    <i>Atg7</i>
                    -deficient mice

Komatsu, Masaaki; Waguri, Satoshi; Ueno, Takashi; Iwata, Junichi; Murata, Shigeo; Tanida, Isei; Ezaki, Junji; Mizushima, Noboru; Ohsumi, Yoshinori; Uchiyama, Yasuo; Kominami, Eiki; Tanaka, Keiji; Chiba, Tomoki

doi:10.1083/jcb.200412022

Public

Impairment of starvation-induced and constitutive autophagy in Atg7 -deficient mice

Shared by NobleBlocks on May 2, 2005 • 12:00 AM UTC

Authors:

Masaaki Komatsu

Satoshi Waguri

Takashi Ueno

Abstract

Autophagy is a membrane-trafficking mechanism that delivers cytoplasmic constituents into the lysosome/vacuole for bulk protein degradation. This mechanism is involved in the preservation of nutrients under starvation condition as well as the normal turnover of cytoplasmic component. Aberrant autoph...

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