Disease‐specific phenotypes in dopamine neurons from human iPS‐based models of genetic and sporadic Parkinson's disease

Sánchez‐Danés, Adriana; Richaud‐Patín, Yvonne; Carballo‐Carbajal, Iria; Jiménez‐Delgado, Senda; Caig, Carles; Mora, Sergio; Di Guglielmo, Claudia; Ezquerra, Mario; Patel, Bindiben; Giralt, Albert; M. Canals, Josep; Memo, Maurizio; Alberch, Jordi; López‐Barneo, José; Vila, Miquel; María Cuervo, Ana; Tolosa, Eduard; Consiglio, Antonella; Raya, Ángel

doi:10.1002/emmm.201200215

Public

Disease‐specific phenotypes in dopamine neurons from human iPS‐based models of genetic and sporadic Parkinson's disease

Published in EMBO Molecular Medicine • Mar 8, 2012

Authors:

Adriana Sánchez‐Danés

Yvonne Richaud‐Patín

Iria Carballo‐Carbajal

Abstract

Induced pluripotent stem cells (iPSC) offer an unprecedented opportunity to model human disease in relevant cell types, but it is unclear whether they could successfully model age-related diseases such as Parkinson's disease (PD). Here, we generated iPSC lines from seven patients with idiopathic PD ...

Subject

LRRK2

Induced pluripotent stem cell

Neurite

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