Diagnosing Severe Falciparum Malaria in Parasitaemic African Children: A Prospective Evaluation of Plasma PfHRP2 Measurement

C. E. Hendriksen, Ilse; Mwanga‐Amumpaire, Juliet; von Seidlein, Lorenz; Mtove, George; J. White, Lisa; Olaosebikan, Rasaq; J. Lee, Sue; Tshefu, Antoinette; J. Woodrow, Charles; Amos, Ben; Karema, Corine; Saiwaew, Somporn; Maitland, Kathryn; Gomes, Ermelinda; Pan–ngum, Wirichada; Gesase, Samwel; Silamut, Kamolrat; Reyburn, Hugh; Joseph, Sarah; Chotivanich, Kesinee; I. Fanello, Caterina; Day, Nicholas; J. White, Nicholas; M. Dondorp, Arjen

doi:10.1371/journal.pmed.1001297

Public

Diagnosing Severe Falciparum Malaria in Parasitaemic African Children: A Prospective Evaluation of Plasma PfHRP2 Measurement

Published in PLoS Medicine • Aug 21, 2012

Authors:

Ilse C. E. Hendriksen

Juliet Mwanga‐Amumpaire

Lorenz von Seidlein

Abstract

BACKGROUND: In African children, distinguishing severe falciparum malaria from other severe febrile illnesses with coincidental Plasmodium falciparum parasitaemia is a major challenge. P. falciparum histidine-rich protein 2 (PfHRP2) is released by mature sequestered parasites and can be used to esti...

Subject

Malaria

Artesunate

Medicine

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