Disruption of Glycine Transporter 1 Restricted to Forebrain Neurons Is Associated with a Procognitive and Antipsychotic Phenotypic Profile

K. Yee, Benjamin; Balic, Ela; Singer, Philipp; Schwerdel, Cornelia; Grampp, Thomas; Gabernet, Laetitia; Knuesel, Irène; Benke, Dietmar; Feldon, Joram; Möhler, Hanns; Boison, Detlev

doi:10.1523/jneurosci.5120-05.2006

Public

Disruption of Glycine Transporter 1 Restricted to Forebrain Neurons Is Associated with a Procognitive and Antipsychotic Phenotypic Profile

Published in Journal of Neuroscience • Mar 22, 2006

Authors:

Benjamin K. Yee

Ela Balic

Philipp Singer

Abstract

The NMDA receptor is thought to play a central role in some forms of neuronal plasticity, including the induction of long-term potentiation. NMDA receptor hypofunction can result in mnemonic impairment and has been implicated in the cognitive symptoms of schizophrenia. The activity of NMDA receptors...

Subject

NMDA receptor

Forebrain

Neuroscience

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