The Association between Common Vitamin D Receptor Gene Variations and Osteoporosis: A Participant-Level Meta-Analysis

G. Uitterlinden, André; H. Ralston, Stuart; Luisa Brandi, Maria; H. Carey, Alisoun; Grinberg, Daniel; Langdahl, Bente; Lips, P.; Lorenc, R; Obermayer-Pietsch, Barbara; Reeve, J.; M. Reid, David; Amedei, Antonietta; Bassiti, Amelia; Bustamante, Mariona; B. Husted, Lise; Díez‐Pérez, Adolfo; Dobnig, Harald; M. Dunning, Alison; Enjuanes, Anna; Fahrleitner‐Pammer, Astrid; Fang, Yue; Karczmarewicz, Elżbieta; Kruk, Marcin; P.T.M. van Leeuwen, Johannes; Mavilia, Carmelo; B. J. van Meurs, Joyce; Mangion, Jon; E. McGuigan, Fiona; A. P. Pols, Huibert; Renner, Wilfried; Rivadeneira, Fernando; M. van Schoor, Natasja; Scollen, Serena; E. Sherlock, Rachael; P. A. Ioannidis, John; APOSS Investigators, and; EPOS Investigators, and; EPOLOS Investigators, and; FAMOS Investigators, and; LASA Investigators, and; Rotterdam Study Investigators, and; the GENOMOS Study*, for

doi:10.7326/0003-4819-145-4-200608150-00005

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The Association between Common Vitamin D Receptor Gene Variations and Osteoporosis: A Participant-Level Meta-Analysis

Published in Annals of Internal Medicine • Aug 15, 2006

Authors:

André G. Uitterlinden

Stuart H. Ralston

Maria Luisa Brandi

Abstract

BACKGROUND: Polymorphisms of the vitamin D receptor (VDR) gene have been implicated in the genetic regulation of bone mineral density (BMD). However, the clinical impact of these variants remains unclear. OBJECTIVE: To evaluate the relation between VDR polymorphisms, BMD, and fractures. DESIGN: Pros...

Subject

Calcitriol receptor

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