Identification of <i>IRAK1</i> as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus

O. Jacob, Chaim; Zhu, Jiankun; Armstrong, Don; Yan, Mei; Han, Jie; J. Zhou, Xin; A. Thomas, James; Reiff, Andreas; L. Myones, Barry; O. Ojwang, Joshua; M. Kaufman, Kenneth; Klein‐Gitelman, Marisa; McCurdy, Deborah; Wagner‐Weiner, Linda; D. Silverman, Earl; T. Ziegler, Julie; A. Kelly, Jennifer; T. Merrill, Joan; B. Harley, John; Ramsey‐Goldman, Rosalind; M. Vilá, Luis; Bae, Sang‐Cheol; J. Vyse, Timothy; S. Gilkeson, Gary; M. Gaffney, Patrick; L. Moser, Kathy; D. Langefeld, Carl; Zidovetzki, Raphael; Mohan, Chandra

doi:10.1073/pnas.0901181106

Public

Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus

Published in Proceedings of the National Academy of Sciences • Mar 30, 2009

Authors:

Chaim O. Jacob

Jiankun Zhu

Don Armstrong

Abstract

A combined forward and reverse genetic approach was undertaken to test the candidacy of IRAK1 (interleukin-1 receptor associated kinase-1) as an X chromosome-encoded risk factor for systemic lupus erythematosus (SLE). In studying approximately 5,000 subjects and healthy controls, 5 SNPs spanning the...

Subject

Immunology

Biology

Single-nucleotide polymorphism

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!