Effect of Hydroxyurea on Mortality and Morbidity in Adult Sickle Cell Anemia

H. Steinberg, Martin; Barton, Franca; Castro, Oswaldo; H. Pegelow, Charles; K. Ballas, Samir; Kutlar, Abdullah; Orringer, Eugene; Bellevue, Rita; Olivieri, Nancy; Eckman, James; Varma, Mala; Ramirez, Gloria; Adler, Brian; Smith, Wally; Carlos, Timothy; Ataga, Kenneth; DeCastro, Laura; Bigelow, Carolyn; Saunthararajah, Yogen; Telfer, Margaret; Vichinsky, Elliott; Claster, Susan; Shurin, Susan; Bridges, Kenneth; Waclawiw, Myron; Bonds, Duane; Terrin, Michael

doi:10.1001/jama.289.13.1645

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Effect of Hydroxyurea on Mortality and Morbidity in Adult Sickle Cell Anemia

Shared by NobleBlocks on Apr 2, 2003 • 12:00 AM UTC

Authors:

Martin H. Steinberg

Franca Barton

Oswaldo Castro

Abstract

Context Hydroxyurea increases levels of fetal hemoglobin (HbF) and decreases morbidity from vaso-occlusive complications in patients with sickle cell anemia (SCA). High HbF levels reduce morbidity and mortality. Objective To determine whether hydroxyurea attenuates mortality in patients with SCA. De...

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