Effect of Hydroxyurea on Mortality and Morbidity in Adult Sickle Cell Anemia

H. Steinberg, Martin; B. Barton, Franca; Castro, Oswaldo; H. Pegelow, Charles; K. Ballas, Samir; Kutlar, Abdullah; P. Orringer, Eugene; Bellevue, Rita; F. Olivieri, Nancy; R. Eckman, James; Varma, Mala; Ramirez, Gloria; K. Adler, Brian; R. Smith, Wally; M. Carlos, Timothy; I. Ataga, Kenneth; DeCastro, Laura; Bigelow, Carolyn; Saunthararajah, Yogen; Telfer, Margaret; Vichinsky, Elliott; Claster, Susan; B. Shurin, Susan; R. Bridges, Kenneth; A. Waclawiw, Myron; R. Bonds, Duane; L. Terrin, Michael

doi:10.1001/jama.289.13.1645

Public

Effect of Hydroxyurea on Mortality and Morbidity in Adult Sickle Cell Anemia

Published in JAMA • Apr 1, 2003

Authors:

Martin H. Steinberg

Franca B. Barton

Oswaldo Castro

Abstract

CONTEXT: Hydroxyurea increases levels of fetal hemoglobin (HbF) and decreases morbidity from vaso-occlusive complications in patients with sickle cell anemia (SCA). High HbF levels reduce morbidity and mortality. OBJECTIVE: To determine whether hydroxyurea attenuates mortality in patients with SCA. ...

Subject

Medicine

Acute chest syndrome

Fetal hemoglobin

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