Role of α<sub>2</sub>-macroglobulin in fever and cytokine responses induced by lipopolysaccharide in mice

V. Gourine, Alexander; N. Gourine, Valery; Tesfaigzi, Yohannes; Caluwaerts, Nathalie; Van Leuven, Fred; J. Kluger, Matthew

doi:10.1152/ajpregu.00746.2001

Public

Role of α2-macroglobulin in fever and cytokine responses induced by lipopolysaccharide in mice

Published in American Journal of Physiology-Regulatory, Integrative and Comparative Physiology • Jul 1, 2002

Authors:

Alexander V. Gourine

Valery N. Gourine

Yohannes Tesfaigzi

Abstract

Alpha(2)-macroglobulin (alpha(2)M) is not only a proteinase inhibitor in mammals, but it is also a specific cytokine carrier that binds pro- and anti-inflammatory cytokines implicated in fever, including interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha (TNF-alpha). To define the role of...

Subject

Lipopolysaccharide

Tumor necrosis factor alpha

Cytokine

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