High-Linear Energy Transfer Irradiation Targeted to Skeletal Metastases by the α-Emitter 223Ra: Adjuvant or Alternative to Conventional Modalities?

S. Bruland, Øyvind; Nilsson, Sten; R. Fisher, Darrell; H. Larsen, Roy

doi:10.1158/1078-0432.ccr-06-0841

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High-Linear Energy Transfer Irradiation Targeted to Skeletal Metastases by the α-Emitter 223Ra: Adjuvant or Alternative to Conventional Modalities?

Shared by NobleBlocks on Oct 15, 2006 • 12:00 AM UTC

Authors:

Øyvind S. Bruland

Sten Nilsson

Darrell R. Fisher

Abstract

Abstract The bone-seeking, α-particle-emitting radiopharmaceutical Alpharadin, 223RaCl2 (half-life = 11.4 days), is under clinical development as a novel treatment for skeletal metastases from breast and prostate cancer. This article summarizes the current status of preclinical and clinical research...

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