Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate

Tamura, Hiroshi; Takasaki, Akihisa; Miwa, Ichiro; Taniguchi, Ken; Maekawa, Ryo; Asada, Hiromi; Taketani, Toshiaki; Matsuoka, Aki; Yamagata, Yoshiaki; Shimamura, Katsunori; Morioka, Hitoshi; Ishikawa, Hitoshi; J. Reiter, Rüssel; Sugino, Norihiro

doi:10.1111/j.1600-079x.2007.00524.x

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Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate

Published in Journal of Pineal Research • Oct 29, 2007

Authors:

Hiroshi Tamura

Akihisa Takasaki

Ichiro Miwa

Abstract

We investigated the relationship between oxidative stress and poor oocyte quality and whether the antioxidant melatonin improves oocyte quality. Follicular fluid was sampled at oocyte retrieval during in vitro fertilization and embryo transfer (IVF-ET). Intrafollicular concentrations of 8-hydroxy-2'...

Subject

Melatonin

Oocyte

Oxidative stress

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