Sequencing of 50 Human Exomes Reveals Adaptation to High Altitude

Yi, Xin; Liang, Yu; Huerta‐Sánchez, Emilia; Jin, Xin; Xi Ping Cuo, Zha; E. Pool, John; Xu, Xun; Jiang, Hui; Vinckenbosch, Nicolas; Sand Korneliussen, Thorfinn; Zheng, Hancheng; Liu, Tao; He, Weiming; Li, Kui; Luo, Ruibang; Nie, Xifang; Wu, Honglong; Zhao, Meiru; Cao, Hongzhi; Zou, Jing; Shan, Ying; Li, Shuzheng; Yang, Qi; , Asan; Ni, Peixiang; Tian, Geng; Xu, Junming; Liu, Xiao; Jiang, Tao; Wu, Renhua; Zhou, Guangyu; Tang, Meifang; Qin, Junjie; Wang, Tong; Feng, Shuijian; Li, Guohong; , Huasang; Luosang, Jiangbai; Wang, Wei; Chen, Fang; Wang, Yading; Zheng, Xiaoguang; Li, Zhuo; Bianba, Zhuoma; Yang, Ge; Wang, Xinping; Tang, Shuhui; Gao, Guoyi; Chen, Yong; Luo, Zhen; Gusang, Lamu; Cao, Zheng; Zhang, Qinghui; Ouyang, Weihan; Ren, Xiaoli; Liang, Huiqing; Zheng, Huisong; Huang, Yebo; Li, Jingxiang; Bolund, Lars; Kristiansen, Karsten; Li, Yingrui; Zhang, Yong; Zhang, Xiuqing; Li, Ruiqiang; Li, Songgang; Yang, Huanming; Nielsen, Rasmus; Wang, Jun; Wang, Jian

doi:10.1126/science.1190371

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Sequencing of 50 Human Exomes Reveals Adaptation to High Altitude

Published in Science • Jul 1, 2010

Authors:

Xin Yi

Yu Liang

Emilia Huerta‐Sánchez

Abstract

Residents of the Tibetan Plateau show heritable adaptations to extreme altitude. We sequenced 50 exomes of ethnic Tibetans, encompassing coding sequences of 92% of human genes, with an average coverage of 18x per individual. Genes showing population-specific allele frequency changes, which represent...

Subject

Biology

Genetics

Single-nucleotide polymorphism

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