Obesity and Metabolic Syndrome in Circadian <i>Clock</i> Mutant Mice

W. Turek, Fred; E. Joshu, Corinne; Kohsaka, Akira; Lin, Emily; Ivanova, Ganka; L. McDearmon, Erin; D. Laposky, Aaron; Losee-Olson, Sue; Easton, Amy; R. Jensen, Dalan; H. Eckel, Robert; S. Takahashi, Joseph; Bass, Joseph

doi:10.1126/science.1108750

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Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice

Published in Science • Apr 21, 2005

Authors:

Fred W. Turek

Corinne E. Joshu

Akira Kohsaka

Abstract

The CLOCK transcription factor is a key component of the molecular circadian clock within pacemaker neurons of the hypothalamic suprachiasmatic nucleus. We found that homozygous Clock mutant mice have a greatly attenuated diurnal feeding rhythm, are hyperphagic and obese, and develop a metabolic syn...

Subject

Circadian rhythm

Suprachiasmatic nucleus

Endocrinology

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