Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits

C. Randall, Joshua; W. Winkler, Thomas; Kutalik, Zoltán; I. Berndt, Sonja; Jackson, Anne; L. Monda, Keri; O. Kilpeläinen, Tuomas; Esko, Tõnu; Mägi, Reedik; Li, Shengxu; Workalemahu, Tsegaselassie; F. Feitosa, Mary; C. Croteau‐Chonka, Damien; R. Day, Felix; Fall, Tove; Ferreira, Teresa; Gustafsson, Stefan; E. Locke, Adam; Mathieson, Iain; Scherag, André; Vedantam, Sailaja; R. Wood, Andrew; Liang, Liming; Steinthórsdóttir, Valgerður; Þorleifsson, Guðmar; T. Dermitzakis, Emmanouil; S. Dimas, Antigone; Karpe, Fredrik; L. Min, Josine; Nicholson, George; J. Clegg, Deborah; N. Person, Thomas; P. Krohn, Jon; Bauer, Sabrina; Buechler, Christa; Eisinger, Kristina; Bonnefond, Amélie; Froguel, Philippe; Investigators, MAGIC; Hottenga, Jouke‐Jan; Prokopenko, Inga; L. Waite, Lindsay; B. Harris, Tamara; V. Smith, Albert; R. Shuldiner, Alan; L. McArdle, Wendy; J. Caulfield, Mark; B. Munroe, Patricia; Grönberg, Henrik; Ida Chen, Yii-Der; Guo, Li; Beckmann, J.; Johnson, Toby; Þorsteinsdóttir, Unnur; Teder‐Laving, Maris; Khaw, Kay‐Tee; J. Wareham, Nicholas; Zhao, Wei; Amin, Najaf; A. Oostra, Ben; T. Kraja, Aldi; A. Province, Michael; Adrienne Cupples, L.; L. Heard‐Costa, Nancy; Kaprio, Jaakko; Ripatti, Samuli; Surakka, Ida; S. Collins, Francis; Saramies, Jouko; Tuomilehto, Jaakko; Jula, Antti; Salomaa, Veikko; Erdmann, Jeanette; Hengstenberg, Christian; Loley, Christina; Schunkert, Heribert; Lamina, Claudia; Wichmann, H.-Erich; Albrecht, Eva; Gieger, Christian; A. Hicks, Andrew; Johansson, Åsa; P. Pramstaller, Peter; Kathiresan, Sekar; K. Speliotes, Elizabeth; W.J.H. Penninx, Brenda; Hartikainen, Anna-Liisa; Järvelin, Marjo‐Riitta; Gyllensten, Ulf; I. Boomsma, Dorret; Campbell, Harry; F. Wilson, James; J. Chanock, Stephen; Farrall, Martin; Goel, Anuj; Medina‐Gómez, Carolina; Rivadeneira, Fernando; Estrada, Karol; G. Uitterlinden, André; Hofman, Albert; Carola Zillikens, M.; den Heijer, Martin; A. Kiemeney, Lambertus; Maschio, Andrea; Hall, Per; P. Tyrer, Jonathan; Teumer, Alexander; Völzke, Henry; Kovács, Péter; Tönjes, Anke; Mangino, Massimo; D. Spector, Tim; Hayward, Caroline; Rudan, Igor; S. Hall, Alistair; J. Samani, Nilesh; Attwood, Antony; G. Sambrook, Jennifer; Hung, Joseph; J. Palmer, Lyle; Lokki, Marja‐Liisa; Sinisalo, Juha; Boucher, Gabrielle; V. Huikuri, Heikki; Lorentzon, Mattias; Ohlsson, Claes; Eklund, Niina; G. Eriksson, Johan; Barlassina, Cristina; Rivolta, Carlo; M. Nolte, Ilja; Snieder, Harold; M. van der Klauw, Melanie; V. van Vliet‐Ostaptchouk, Jana; V. Gejman, Pablo; Shi, Jianxin; B. Jacobs, Kevin; Wang, Zhaoming; J. L. Bakker, Stephan; Mateo Leach, Irene; Navis, Gerjan; van der Harst, Pim; G. Martin, Nicholas; E. Medland, Sarah; W. Montgomery, Grant; Yang, Jian; I. Chasman, Daniel; M. Ridker, Paul; M. Rose, Lynda; Lehtimäki, Terho; T. Raitakari, Olli; Absher, Devin; Iribarren, Carlos; Basart, Hanneke; Hovingh, Kees; Hyppönen, Elina; Power, Chris; Anderson, Denise; Beilby, John; Hui, Jennie; Jolley, Jennifer; B. Sager, Hendrik; R. Bornstein, Stefan; Schwarz, Peter; Kristiansson, Kati; Perola, Markus; Lindström, Jaana; J. Swift, Amy; Uusitupa, Matti; Atalay, Mustafa; A. Lakka, Timo; Rauramaa, Rainer; L. Bolton, Jennifer; Fowkes, Gerry; M. Fraser, Ross; F. Price, Jackie; Fischer, Krista; KrjutÅ¡kov, Kaarel; Metspalu, Andres; Mihailov, Evelin; Langenberg, Claudia; Luan, Jian’an; K. Ong, Ken; S. Chines, Peter; Keinänen‐Kiukaanniemi, Sirkka; Saaristo, Timo; Edkins, Sarah; W. Franks, Paul; Hallmans, Göran; Shungin, Dmitry; David Morris, Andrew; N. A. Palmer, Colin; Erbel, Raimund; Moebus, Susanne; M. Nöthen, Markus; Pechlivanis, Sonali; Hveem, Kristian; Narisu, Narisu; Hamsten, Anders; E. Humphries, Steve; J. Strawbridge, Rona; Tremoli, Elena; Grallert, Harald; Thorand, Barbara; Illig, Thomas; Köenig, Wolfgang; Müller‐Nurasyid, Martina; Peters, Annette; O. Boehm, Bernhard; E. Kleber, Marcus; März, Winfried; R. Winkelmann, Bernhard; Kuusisto, Johanna; Laakso, Markku; Arveiler, Dominique; Cesana, Giancarlo; Kuulasmaa, Kari; Virtamo, Jarmo; W. G. Yarnell, J.; Kuh, Diana; Wong, Andrew; Lind, Lars; dé Fairé, Ulf; Gigante, Bruna; K. E. Magnusson, Patrik; L. Pedersen, Nancy; Dedoussis, George; Dimitriou, Maria; Kolovou, Genovefa; Kanoni, Stavroula; Stirrups, Kathleen; L. Bonnycastle, Lori; Njølstad, Inger; Wilsgaard, Tom; Ganna, Andrea; Rehnberg, Emil; D. Hingorani, Aroon; Kivimäki, Mika; Kumari, Meena; L. Assimes, Themistocles; Barroso, Inês; Boehnke, Michael; B. Borecki, Ingrid; Deloukas, Panos; S. Fox, Caroline; M. Frayling, Timothy; C. Groop, Leif; Haritunians, Talin; J. Hunter, David; Ingelsson, Erik; C. Kaplan, Robert; L. Mohlke, Karen; R. O’Connell, Jeffrey; Schlessinger, David; P. Strachan, David; Stefánsson, Kāri; M. van Duijn, Cornelia; R. Abecasis, Gonçalo; I. McCarthy, Mark; N. Hirschhorn, Joel; Qi, Lu; J. F. Loos, Ruth; M. Lindgren, Cecilia; E. North, Kari; M. Heid, Iris

doi:10.1371/journal.pgen.1003500

Public

Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits

Published in PLoS Genetics • Jun 6, 2013

Authors:

Joshua C. Randall

Thomas W. Winkler

Zoltán Kutalik

Abstract

Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio (133,723 i...

Subject

Biology

Sexual dimorphism

Genome-wide association study

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