Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits

C. Randall, Joshua; W. Winkler, Thomas; Kutalik, Zoltán; I. Berndt, Sonja; U. Jackson, Anne; L. Monda, Keri; O. Kilpeläinen, Tuomas; Esko, Tõnu; Mägi, Reedik; Li, Shengxu; Workalemahu, Tsegaselassie; F. Feitosa, Mary; C. Croteau-Chonka, Damien; R. Day, Felix; Fall, Tove; Ferreira, Teresa; Gustafsson, Stefan; E. Locke, Adam; Mathieson, Iain; Scherag, Andre; Vedantam, Sailaja; R. Wood, Andrew; Liang, Liming; Steinthorsdottir, Valgerdur; Thorleifsson, Gudmar; T. Dermitzakis, Emmanouil; S. Dimas, Antigone; Karpe, Fredrik; L. Min, Josine; Nicholson, George; J. Clegg, Deborah; Person, Thomas; P. Krohn, Jon; Bauer, Sabrina; Buechler, Christa; Eisinger, Kristina; Consortium, DIAGRAM; Bonnefond, Amélie; Froguel, Philippe; Investigators, MAGIC; Hottenga, Jouke-Jan; Prokopenko, Inga; L. Waite, Lindsay; B. Harris, Tamara; Vernon Smith, Albert; R. Shuldiner, Alan; L. McArdle, Wendy; J. Caulfield, Mark; B. Munroe, Patricia; Grönberg, Henrik; Ida Chen, Yii-Der; Li, Guo; S. Beckmann, Jacques; Johnson, Toby; Thorsteinsdottir, Unnur; Teder-Laving, Maris; Khaw, Kay-Tee; J. Wareham, Nicholas; Hua Zhao, Jing; Amin, Najaf; A. Oostra, Ben; T. Kraja, Aldi; A. Province, Michael; Adrienne Cupples, L.; L. Heard-Costa, Nancy; Kaprio, Jaakko; Ripatti, Samuli; Surakka, Ida; S. Collins, Francis; Saramies, Jouko; Tuomilehto, Jaakko; Jula, Antti; Salomaa, Veikko; Erdmann, Jeanette; Hengstenberg, Christian; Loley, Christina; Schunkert, Heribert; Lamina, Claudia; Erich Wichmann, H.; Albrecht, Eva; Gieger, Christian; A. Hicks, Andrew; Johansson, Åsa; P. Pramstaller, Peter; Kathiresan, Sekar; K. Speliotes, Elizabeth; Penninx, Brenda; Hartikainen, Anna-Liisa; Jarvelin, Marjo-Riitta; Gyllensten, Ulf; I. Boomsma, Dorret; Campbell, Harry; F. Wilson, James; J. Chanock, Stephen; Farrall, Martin; Goel, Anuj; Medina-Gomez, Carolina; Rivadeneira, Fernando; Estrada, Karol; G. Uitterlinden, André; Hofman, Albert; Carola Zillikens, M.; den Heijer, Martin; A. Kiemeney, Lambertus; Maschio, Andrea; Hall, Per; Tyrer, Jonathan; Teumer, Alexander; Völzke, Henry; Kovacs, Peter; Tönjes, Anke; Mangino, Massimo; D. Spector, Tim; Hayward, Caroline; Rudan, Igor; S. Hall, Alistair; J. Samani, Nilesh; Paul Attwood, Antony; G. Sambrook, Jennifer; Hung, Joseph; J. Palmer, Lyle; Lokki, Marja-Liisa; Sinisalo, Juha; Boucher, Gabrielle; Huikuri, Heikki; Lorentzon, Mattias; Ohlsson, Claes; Eklund, Niina; G. Eriksson, Johan; Barlassina, Cristina; Rivolta, Carlo; M. Nolte, Ilja; Snieder, Harold; M. Van der Klauw, Melanie; V. Van Vliet-Ostaptchouk, Jana; V. Gejman, Pablo; Shi, Jianxin; B. Jacobs, Kevin; Wang, Zhaoming; J. L. Bakker, Stephan; Mateo Leach, Irene; Navis, Gerjan; van der Harst, Pim; G. Martin, Nicholas; E. Medland, Sarah; W. Montgomery, Grant; Yang, Jian; I. Chasman, Daniel; M. Ridker, Paul; M. Rose, Lynda; Lehtimäki, Terho; Raitakari, Olli; Absher, Devin; Iribarren, Carlos; Basart, Hanneke; G. Hovingh, Kees; Hyppönen, Elina; Power, Chris; Anderson, Denise; P. Beilby, John; Hui, Jennie; Jolley, Jennifer; Sager, Hendrik; R. Bornstein, Stefan; E. H. Schwarz, Peter; Kristiansson, Kati; Perola, Markus; Lindström, Jaana; J. Swift, Amy; Uusitupa, Matti; Atalay, Mustafa; A. Lakka, Timo; Rauramaa, Rainer; L. Bolton, Jennifer; Fowkes, Gerry; M. Fraser, Ross; F. Price, Jackie; Fischer, Krista; KrjutÅ¡kov, Kaarel; Metspalu, Andres; Mihailov, Evelin; Langenberg, Claudia; Luan, Jian'an; K. Ong, Ken; S. Chines, Peter; M. Keinanen-Kiukaanniemi, Sirkka; E. Saaristo, Timo; Edkins, Sarah; W. Franks, Paul; Hallmans, Göran; Shungin, Dmitry; David Morris, Andrew; N. A. Palmer, Colin; Erbel, Raimund; Moebus, Susanne; M. Nöthen, Markus; Pechlivanis, Sonali; Hveem, Kristian; Narisu, Narisu; Hamsten, Anders

doi:10.1371/journal.pgen.1003500

Public

Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits

Shared by NobleBlocks on Jun 6, 2013 • 12:00 AM UTC

Authors:

Joshua C. Randall

Thomas W. Winkler

Zoltán Kutalik

Research Assistant

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