Mineralocorticoid Action: Target Tissue Specificity Is Enzyme, Not Receptor, Mediated

W. Funder, John; Pearce, P.; Smith, Robin; Ian Smith, A.

doi:10.1126/science.2845584

Public

Mineralocorticoid Action: Target Tissue Specificity Is Enzyme, Not Receptor, Mediated

Published in Science • Oct 28, 1988

Authors:

John W. Funder

P. Pearce

Robin Smith

Abstract

Mineralocorticoid receptors, both when in tissue extracts and when recombinant-derived, have equal affinity for the physiological mineralocorticoid aldosterone and for the glucocorticoids cortisol and corticosterone, which circulate at much higher concentrations than aldosterone. Such receptors are ...

Subject

Mineralocorticoid

Mineralocorticoid receptor

Corticosterone

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