CCR2+ monocytes infiltrate atrophic lesions in age‐related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice

Sennlaub, Florian; Auvynet, Constance; Calippe, Bertrand; Lavalette, Sophie; Poupel, Lucie; J. Hu, Shulong; Dominguez, Elisa; Camelo, Serge; Levy, Olivier; Guyon, Elodie; Saederup, Noah; Charo, Israel; van Rooijen, Nico; F. Nandrot, Emeline; Bourges, Jean‐Louis; Béhar‐Cohen, Francine; Sahel, José‐Alain; Guillonneau, Xavier; Raoul, William; Combadière, Christophe

doi:10.1002/emmm.201302692

Public

CCR2+ monocytes infiltrate atrophic lesions in age‐related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice

Published in EMBO Molecular Medicine • Oct 21, 2013

Authors:

Florian Sennlaub

Constance Auvynet

Bertrand Calippe

Abstract

Atrophic age-related macular degeneration (AMD) is associated with the subretinal accumulation of mononuclear phagocytes (MPs). Their role in promoting or inhibiting retinal degeneration is unknown. We here show that atrophic AMD is associated with increased intraocular CCL2 levels and subretinal CC...

Subject

CCR2

Macular degeneration

CCL2

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