Targetable Kinase-Activating Lesions in Ph-like Acute Lymphoblastic Leukemia

G. Roberts, Kathryn; Li, Yongjin; Payne-Turner, Debbie; C. Harvey, Richard; Yang, Yung‐Li; Pei, Deqing; McCastlain, Kelly; Ding, Li; Lu, Charles; Song, Guangchun; Ma, Jing; Becksfort, Jared; Rusch, Michael; Chen, Shann-Ching; Easton, John; Cheng, Jinjun; Boggs, Kristy; Santiago-Morales, Natalia; Iacobucci, Ilaria; S. Fulton, Robert; Wen, Ji; Valentine, Marcus; Cheng, Cheng; W. Paugh, Steven; Devidas, Meenakshi; Chen, I‐Ming; C. Reshmi, Shalini; Smith, Amy; Hedlund, Erin; Gupta, Pankaj; Nagahawatte, Panduka; Wu, Gang; Chen, Xiang; Yergeau, Donald; Vadodaria, Bhavin; L. Mulder, Heather; Winick, Naomi; Larsen, Eric; L. Carroll, William; A. Heerema, Nyla; J. Carroll, Andrew; H. Grayson, Guy; K. Tasian, Sarah; S. Moore, Andrew; Keller, Frank; Frei‐Jones, Melissa; A. Whitlock, James; A. Raetz, Elizabeth; L. White, Deborah; P. Hughes, Timothy; M. Guidry Auvil, Jaime; A. Smith, Malcolm; Marcucci, Guido; D. Bloomfield, Clara; Mrózek, Krzysztof; Kohlschmidt, Jessica; Stock, Wendy; M. Kornblau, Steven; Konopleva, Marina; Paietta, Elisabeth; Pui, Ching‐Hon; Jeha, Sima; V. Relling, Mary; E. Evans, William; S. Gerhard, Daniela; M. Gastier-Foster, Julie; R. Mardis, Elaine; K. Wilson, Richard; L. Loh, Mignon; R. Downing, James; P. Hunger, Stephen; L. Willman, Cheryl; Zhang, Jinghui; G. Mullighan, Charles

doi:10.1056/nejmoa1403088

Public

Targetable Kinase-Activating Lesions in Ph-like Acute Lymphoblastic Leukemia

Published in New England Journal of Medicine • Sep 11, 2014

Authors:

Kathryn G. Roberts

Yongjin Li

Debbie Payne-Turner

Abstract

BACKGROUND: Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is characterized by a gene-expression profile similar to that of BCR-ABL1-positive ALL, alterations of lymphoid transcription factor genes, and a poor outcome. The frequency and spectrum of genetic alterations in Ph-...

Subject

Lymphoblastic Leukemia

Tyrosine kinase

Cancer research

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!