Haplotype diversity and linkage disequilibrium at human G6PD: recent origin of alleles that confer malarial resistance.

SA, Tishkoff; R, Varkonyi; N, Cahinhinan; S, Abbes; G, Argyropoulos; G, Destro-Bisol; A, Drousiotou; B, Dangerfield; G, Lefranc; G, Lefranc; J, Loiselet; A, Piro; M, Stoneking; A, Tagarelli; G, Tagarelli; EH, Touma; SM, Williams; AG, Clark

doi:10.1126/science.1061573

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Haplotype diversity and linkage disequilibrium at human G6PD: recent origin of alleles that confer malarial resistance.

Shared by NobleBlocks on Jun 21, 2001 • 12:00 AM UTC

Authors:

Tishkoff SA

Varkonyi R

Cahinhinan N

Abstract

The frequencies of low-activity alleles of glucose-6-phosphate dehydrogenase in humans are highly correlated with the prevalence of malaria. These "deficiency" alleles are thought to provide reduced risk from infection by the Plasmodium parasite and are maintained at high frequency despite the hemop...

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