Haplotype Diversity and Linkage Disequilibrium at Human <i>G6PD</i> : Recent Origin of Alleles That Confer Malarial Resistance

A. Tishkoff, Sarah; Varkonyi, Robert; Cahinhinan, Nelie; Abbès, Salem; Argyropoulos, George; Destro‐Bisol, Giovanni; Drousiotou, Anthi; Dangerfield, Bruce; Lefranc, Gerard; Loiselet, Jacques; Piro, Anna; Stoneking, Mark; Tagarelli, Antonio; Tagarelli, Giuseppe; H Touma, Elias; M. Williams, Scott; G. Clark, Andrew

doi:10.1126/science.1061573

Public

Haplotype Diversity and Linkage Disequilibrium at Human G6PD : Recent Origin of Alleles That Confer Malarial Resistance

Published in Science • Jul 20, 2001

Authors:

Sarah A. Tishkoff

Robert Varkonyi

Nelie Cahinhinan

Abstract

The frequencies of low-activity alleles of glucose-6-phosphate dehydrogenase in humans are highly correlated with the prevalence of malaria. These "deficiency" alleles are thought to provide reduced risk from infection by the Plasmodium parasite and are maintained at high frequency despite the hemop...

Subject

Allele

Linkage disequilibrium

Biology

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