Reciprocal Modulation of Toll-like Receptor-4 Signaling Pathways Involving MyD88 and Phosphatidylinositol 3-Kinase/AKT by Saturated and Polyunsaturated Fatty Acids

Young Lee, Joo; Ye, Jianping; Gao, Zhan‐Guo; S. Youn, Hyung; Hee Lee, Won; Zhao, Ling; Sizemore, Nywana; Hwang, Daniel

doi:10.1074/jbc.m305213200

Public

Reciprocal Modulation of Toll-like Receptor-4 Signaling Pathways Involving MyD88 and Phosphatidylinositol 3-Kinase/AKT by Saturated and Polyunsaturated Fatty Acids

Published in Journal of Biological Chemistry • Sep 1, 2003

Authors:

Joo Young Lee

Jianping Ye

Zhan‐Guo Gao

Abstract

Toll-like receptor-4 (TLR4) can be activated by nonbacterial agonists, including saturated fatty acids. However, downstream signaling pathways activated by nonbacterial agonists are not known. Thus, we determined the downstream signaling pathways derived from saturated fatty acid-induced TLR4 activa...

Subject

Protein kinase B

PI3K/AKT/mTOR pathway

Signal transduction

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