Cutting Edge: A Novel Toll/IL-1 Receptor Domain-Containing Adapter That Preferentially Activates the IFN-β Promoter in the Toll-Like Receptor Signaling

Yamamoto, Masahiro; Sato, Shintaro; Mori, Kiyotoshi; Hoshino, Katsuaki; Takeuchi, Osamu; Takeda, Kiyoshi; Akira, Shizuo

doi:10.4049/jimmunol.169.12.6668

Public

Cutting Edge: A Novel Toll/IL-1 Receptor Domain-Containing Adapter That Preferentially Activates the IFN-β Promoter in the Toll-Like Receptor Signaling

Shared by NobleBlocks on Dec 1, 2002 • 12:00 AM UTC

Authors:

Masahiro Yamamoto

Shintaro Sato

Kiyotoshi Mori

Abstract

Abstract MyD88 is a Toll/IL-1 receptor (TIR) domain-containing adapter common to signaling pathways via Toll-like receptor (TLR) family. However, accumulating evidence demonstrates the existence of a MyD88-independent pathway, which may explain unique biological responses of individual TLRs, particu...

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