Adoptive Cell Transfer Therapy Following Non-Myeloablative but Lymphodepleting Chemotherapy for the Treatment of Patients With Refractory Metastatic Melanoma

E. Dudley, Mark; R. Wunderlich, John; Chih‐Hsin Yang, James; M. Sherry, Richard; L. Topalian, Suzanne; P. Restifo, Nicholas; E. Royal, Richard; S. Kammula, Udai; E White, D; Mavroukakis, Sharon; Rogers, Linda; Gracia, Gerald; A. Jones, Stephanie; P. Mangiameli, David; M. Pelletier, Michelle; Gea‐Banacloche, Juan; R. Robinson, Michael; M. Berman, David; Filie, Armando; Abati, Andrea; A. Rosenberg, Steven

doi:10.1200/jco.2005.00.240

Public

Adoptive Cell Transfer Therapy Following Non-Myeloablative but Lymphodepleting Chemotherapy for the Treatment of Patients With Refractory Metastatic Melanoma

Published in Journal of Clinical Oncology • Mar 30, 2005

Authors:

Mark E. Dudley

John R. Wunderlich

James Chih‐Hsin Yang

Abstract

PURPOSE: We investigated the combination of lymphodepleting chemotherapy followed by the adoptive transfer of autologous tumor reactive lymphocytes for the treatment of patients with refractory metastatic melanoma. PATIENTS AND METHODS: Thirty-five patients with metastatic melanoma, all but one with...

Subject

Medicine

Fludarabine

Chemotherapy

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