Adoptive Cell Transfer Therapy Following Non-Myeloablative but Lymphodepleting Chemotherapy for the Treatment of Patients With Refractory Metastatic Melanoma

E. Dudley, Mark; R. Wunderlich, John; C. Yang, James; M. Sherry, Richard; L. Topalian, Suzanne; P. Restifo, Nicholas; E. Royal, Richard; Kammula, Udai; E. White, Don; A. Mavroukakis, Sharon; J. Rogers, Linda; J. Gracia, Gerald; A. Jones, Stephanie; P. Mangiameli, David; M. Pelletier, Michelle; Gea-Banacloche, Juan; R. Robinson, Michael; M. Berman, David; C. Filie, Armando; Abati, Andrea; A. Rosenberg, Steven

doi:10.1200/jco.2005.00.240

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Adoptive Cell Transfer Therapy Following Non-Myeloablative but Lymphodepleting Chemotherapy for the Treatment of Patients With Refractory Metastatic Melanoma

Shared by NobleBlocks on Apr 1, 2005 • 12:00 AM UTC

Authors:

Mark E. Dudley

John R. Wunderlich

James C. Yang

Abstract

Purpose We investigated the combination of lymphodepleting chemotherapy followed by the adoptive transfer of autologous tumor reactive lymphocytes for the treatment of patients with refractory metastatic melanoma. Patients and Methods Thirty-five patients with metastatic melanoma, all but one with d...

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