Genetic Association and Expression Studies Indicate a Role of Toll-Like Receptor 8 in Pulmonary Tuberculosis

Dávila, Sonia; L. Hibberd, Martin; Hari Dass, Ranjeeta; E. E. Wong, Hazel; Sahiratmadja, Edhyana; Bonnard, Carine; Alisjahbana, Bachti; S. Szeszko, Jeffrey; Balabanova, Yanina; Drobniewski, Francis; van Crevel, Reinout; van de Vosse, Esther; Nejentsev, Sergey; H. M. Ottenhoff, Tom; Seielstad, Mark

doi:10.1371/journal.pgen.1000218

Public

Genetic Association and Expression Studies Indicate a Role of Toll-Like Receptor 8 in Pulmonary Tuberculosis

Published in PLoS Genetics • Oct 9, 2008

Authors:

Sonia Dávila

Martin L. Hibberd

Ranjeeta Hari Dass

Abstract

Despite high rates of exposure, only 5-10% of people infected with Mycobacterium tuberculosis will develop active tuberculosis (TB) disease, suggesting a significant role for genetic variation in the human immune response to this infection. Here, we studied TB association and expression of 18 genes ...

Subject

Biology

Tuberculosis

Immunology

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