Munc18-2 and Syntaxin 3 Control Distinct Essential Steps in Mast Cell Degranulation

Brochetta, Cristiana; Suzuki, Ryo; Vita, Francesca; Rosa Soranzo, Maria; Claver, Julien; Celia Madjène, Lydia; Attout, Tarik; Vitte, Joana; Varin‐Blank, Nadine; Zabucchi, Giuliano; Rivera, Juan; Blank, Ulrich

doi:10.4049/jimmunol.1301277

Public

Munc18-2 and Syntaxin 3 Control Distinct Essential Steps in Mast Cell Degranulation

Published in The Journal of Immunology • Dec 10, 2013

Authors:

Cristiana Brochetta

Ryo Suzuki

Francesca Vita

Abstract

Mast cell degranulation requires N-ethylmaleimide-sensitive factor attachment protein receptors (SNARE) and mammalian uncoordinated18 (Munc18) fusion accessory proteins for membrane fusion. However, it is still unknown how their interaction supports fusion. In this study, we found that small interfe...

Subject

Cell biology

Nocodazole

Degranulation

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