βig-h3, a Transforming Growth Factor–β–Inducible Gene, Is Overexpressed in Atherosclerotic and Restenotic Human Vascular Lesions

R. O’Brien, Edward; L. Bennett, Kelly; R. Garvin, Michael; W. Zderic, Ted; Hinohara, Tomoaki; B. Simpson, John; Kimura, Takeshi; Nobuyoshi, Masakiyo; F. Mizgala, Henry; F Purchio, A; M. Schwartz, Stephen

doi:10.1161/01.atv.16.4.576

Public

βig-h3, a Transforming Growth Factor–β–Inducible Gene, Is Overexpressed in Atherosclerotic and Restenotic Human Vascular Lesions

Published in Arteriosclerosis Thrombosis and Vascular Biology • Apr 1, 1996

Authors:

Edward R. O’Brien

Kelly L. Bennett

Michael R. Garvin

Abstract

Transforming growth factor-beta (TGF-beta) plays an important role in vascular lesion formation and possibly the renarrowing process ("restenosis") that occurs after balloon angioplasty. Secreted in a latent form by most cells, TFG-beta requires enzymatic conversion before it is biologically active....

Subject

Transforming growth factor

Cancer research

Gene

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