Pluripotent stem cell-engineered cell sheets reassembled with defined cardiovascular populations ameliorate reduction in infarct heart function through cardiomyocyte-mediated neovascularization.

H, Masumoto; T, Matsuo; K, Yamamizu; H, Uosaki; G, Narazaki; S, Katayama; A, Marui; T, Shimizu; T, Ikeda; T, Okano; R, Sakata; JK, Yamashita

doi:10.1002/stem.1089

Public

Pluripotent stem cell-engineered cell sheets reassembled with defined cardiovascular populations ameliorate reduction in infarct heart function through cardiomyocyte-mediated neovascularization.

Shared by NobleBlocks on Jun 1, 2012 • 12:00 AM UTC

Authors:

Masumoto H

Matsuo T

Yamamizu K

Abstract

Although stem cell therapy is a promising strategy for cardiac restoration, the heterogeneity of transplanted cells has been hampering the precise understanding of the cellular and molecular mechanisms. Previously, we established a cardiovascular cell differentiation system from mouse pluripotent st...

Discussions