Whole Genome Deep Sequencing of HIV-1 Reveals the Impact of Early Minor Variants Upon Immune Recognition During Acute Infection

R. Henn, Matthew; L. Boutwell, Christian; Charlebois, Patrick; J. Lennon, Niall; A. Power, Karen; R. Macalalad, Alexander; M. Berlin, Aaron; M. Malboeuf, Christine; M. Ryan, Elizabeth; Gnerre, Sante; C. Zody, Michael; Erlich, Rachel; M. Green, Lisa; Berical, Andrew; Wang, Yao‐Yu; Casali, Monica; Streeck, Hendrik; K. Bloom, Allyson; Dudek, Tim; C. Tully, Damien; M. Newman, Ruchi; L. Axten, Karen; D. Gladden, Adrianne; Battis, Laura; Kemper, Michael; Zeng, Qiandong; Shea, Terrance; Gujja, Sharvari; Zedlack, Carmen; Gasser, Olivier; Brander, Christian; Hess, Christoph; F. Günthard, Huldrych; L. Brumme, Zabrina; J. Brumme, Chanson; Bazner, Suzane; Rychert, Jenna; P. Tinsley, Jake; Mayer, Ken; Rosenberg, Eric; Pereyra, Florencia; Z. Levin, Joshua; Young, Sarah; Jessen, Heiko; Altfeld, Marcus; W. Birren, Bruce; D. Walker, Bruce; M. Allen, Todd

doi:10.1371/journal.ppat.1002529

Public

Whole Genome Deep Sequencing of HIV-1 Reveals the Impact of Early Minor Variants Upon Immune Recognition During Acute Infection

Published in PLoS Pathogens • Mar 8, 2012

Authors:

Matthew R. Henn

Christian L. Boutwell

Patrick Charlebois

Abstract

Deep sequencing technologies have the potential to transform the study of highly variable viral pathogens by providing a rapid and cost-effective approach to sensitively characterize rapidly evolving viral quasispecies. Here, we report on a high-throughput whole HIV-1 genome deep sequencing platform...

Subject

Viral quasispecies

Biology

Viremia

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