Intensive Insulin Therapy and Pentastarch Resuscitation in Severe Sepsis

M. Brunkhorst, Frank; Engel, Christoph; Bloos, Frank; Meier‐Hellmann, Andreas; Ragaller, Max; Weiler, Norbert; Moerer, Onnen; Gruendling, Matthias; Oppert, Michael; Grond, Stefan; Olthoff, D; Jaschinski, Ulrich; John, Stefan; Rossaint, Rolf; Welte, Tobias; Schaefer, Martin; Kern, Peter; Kuhnt, Evelyn; Kiehntopf, Michael; S. Hartog, Christiane; Natanson, Charles; Loeffler, Markus; Reinhart, Konrad

doi:10.1056/nejmoa070716

Public

Intensive Insulin Therapy and Pentastarch Resuscitation in Severe Sepsis

Published in New England Journal of Medicine • Jan 9, 2008

Authors:

Frank M. Brunkhorst

Christoph Engel

Frank Bloos

Abstract

BACKGROUND: The role of intensive insulin therapy in patients with severe sepsis is uncertain. Fluid resuscitation improves survival among patients with septic shock, but evidence is lacking to support the choice of either crystalloids or colloids. METHODS: In a multicenter, two-by-two factorial tri...

Subject

Medicine

Resuscitation

Sepsis

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