Genomic Analysis Reveals That Immune Function Genes Are Strongly Linked to Clinical Outcome in the North Central Cancer Treatment Group N9831 Adjuvant Trastuzumab Trial

A. Perez, Edith; Aubrey Thompson, E.; V. Ballman, Karla; Keith Anderson, S.; W. Asmann, Yan; R. Kalari, Krishna; E. Eckel-Passow, Jeanette; C. Dueck, Amylou; S. Tenner, Kathleen; Jen, Jin; Fan, Jian-Bing; J. Geiger, Xochiquetzal; E. McCullough, Ann; Chen, Beiyun; B. Jenkins, Robert; W. Sledge, George; P. Winer, Eric; R. Gralow, Julie; M. Reinholz, Monica

doi:10.1200/jco.2014.57.6298

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Genomic Analysis Reveals That Immune Function Genes Are Strongly Linked to Clinical Outcome in the North Central Cancer Treatment Group N9831 Adjuvant Trastuzumab Trial

Shared by NobleBlocks on Mar 1, 2015 • 12:00 AM UTC

Authors:

Edith A. Perez

E. Aubrey Thompson

Karla V. Ballman

Abstract

Purpose To develop a genomic signature that predicts benefit from trastuzumab in human epidermal growth factor receptor 2–positive breast cancer. Patients and Methods DASL technology was used to quantify mRNA in samples from 1,282 patients enrolled onto the Combination Chemotherapy With or Without T...

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