The major human AP endonuclease (Ape1) is involved in the nucleotide incision repair pathway

Gros, Laurent

doi:10.1093/nar/gkh165

Public

The major human AP endonuclease (Ape1) is involved in the nucleotide incision repair pathway

Published in Nucleic Acids Research • Jan 2, 2004

Authors:

Laurent Gros

Abstract

In nucleotide incision repair (NIR), an endonuclease nicks oxidatively damaged DNA in a DNA glycosylase-independent manner, providing the correct ends for DNA synthesis coupled to the repair of the remaining 5'-dangling modified nucleotide. This mechanistic feature is distinct from DNA glycosylase-m...

Subject

AP site

AP endonuclease

DNA glycosylase

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