Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

R. Wise, David; S. Ward, Patrick; E.S. Shay, Jessica; R. Cross, Justin; J. Gruber, Joshua; M. Sachdeva, Uma; M. Platt, Jesse; G. Dematteo, Raymond; Celeste Simon, M.; B. Thompson, Craig

doi:10.1073/pnas.1117773108

Public

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

Published in Proceedings of the National Academy of Sciences • Nov 21, 2011

Authors:

David R. Wise

Patrick S. Ward

Jessica E.S. Shay

Abstract

Citrate is a critical metabolite required to support both mitochondrial bioenergetics and cytosolic macromolecular synthesis. When cells proliferate under normoxic conditions, glucose provides the acetyl-CoA that condenses with oxaloacetate to support citrate production. Tricarboxylic acid (TCA) cyc...

Subject

Glutamine

Citrate synthase

Citric acid cycle

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!