Efficient genome engineering in human pluripotent stem cells using Cas9 from
                    <i>Neisseria meningitidis</i>

Hou, Zhonggang; Zhang, Yan; E. Propson, Nicholas; E. Howden, Sara; Chu, Li-Fang; J. Sontheimer, Erik; A. Thomson, James

doi:10.1073/pnas.1313587110

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Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis

Shared by NobleBlocks on Aug 12, 2013 • 12:00 AM UTC

Authors:

Zhonggang Hou

Yan Zhang

Nicholas E. Propson

Abstract

Significance Genome engineering in human pluripotent stem cells holds great promise for biomedical research and regenerative medicine, but it is very challenging. Recently, an RNA-guided nuclease system called clustered, regularly interspaced, short palindromic repeats (CRISPR)/CRISPR-associated (Ca...

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