Increased telomere fragility and fusions resulting from <i>TRF1</i> deficiency lead to degenerative pathologies and increased cancer in mice

Martínez, Paula; Thanasoula, Maria; Muñoz, Purificacı́on; Liao, Chunyan; M. Tejera, Águeda; J. McNees, Carolyn; M. Flores, Juana; Fernández-Capetillo, Óscar; Tarsounas, Madalena; A. Blasco, Marı́a

doi:10.1101/gad.543509

Public

Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice

Published in Genes & Development • Aug 13, 2009

Authors:

Paula Martínez

Maria Thanasoula

Purificacı́on Muñoz

Abstract

The telomere repeat-binding factor 1 (TERF1, referred to hereafter as TRF1) is a component of mammalian telomeres whose role in telomere biology and disease has remained elusive. Here, we report on cells and mice conditionally deleted for TRF1. TRF1-deleted mouse embryonic fibroblasts (MEFs) show ra...

Subject

Telomere

Biology

DNA damage

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