Chronic Elevation of Parathyroid Hormone in Mice Reduces Expression of Sclerostin by Osteocytes: A Novel Mechanism for Hormonal Control of Osteoblastogenesis

Bellido, Teresita; Ali, Arshad; Gubrij, Igor; I. Plotkin, Lilian; Fu, Qiang; A. O’Brien, Charles; C. Manolagas, Stavros; L Jilka, R

doi:10.1210/en.2005-0239

Public

Chronic Elevation of Parathyroid Hormone in Mice Reduces Expression of Sclerostin by Osteocytes: A Novel Mechanism for Hormonal Control of Osteoblastogenesis

Published in Endocrinology • Aug 5, 2005

Authors:

Teresita Bellido

Arshad Ali

Igor Gubrij

Abstract

Both chronic excess of PTH, as in hyperparathyroidism, and intermittent elevation of PTH (by daily injections) increase the number of osteoblasts; albeit, the former is associated with bone catabolism and the later with bone anabolism. Intermittent PTH increases osteoblast number by attenuating oste...

Subject

Sclerostin

Endocrinology

Internal medicine

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