Insulin-like growth factor I mediates selective anabolic effects of parathyroid hormone in bone cultures.

Canalis, Ernesto; M. Burch, Warner; L. McCarthy, Thomas

doi:10.1172/jci113885

Public

Insulin-like growth factor I mediates selective anabolic effects of parathyroid hormone in bone cultures.

Published in Journal of Clinical Investigation • Jan 1, 1989

Authors:

Ernesto Canalis

Warner M. Burch

Thomas L. McCarthy

Abstract

PTH was studied for its effects on bone formation in cultured rat calvariae. 0.01-10 nM PTH stimulated [3H]thymidine incorporation into DNA by up to 4.8-fold. Although continuous treatment with PTH for 24-72 h inhibited [3H]proline incorporation into collagen, transient (24 h) treatment enhanced [3H...

Subject

Internal medicine

Endocrinology

Parathyroid hormone

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