Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma

Guillaumond, Fabienne; Leca, Julie; Porta Olivares, O.; Lavaut, Marie‐Noëlle; Vidal, Nicolas; Berthézène, Patrice; Dusetti, Nelson; Loncle, Céline; Calvo, Ézéquiel; Turrini, Olivıer; Iovanna, Juan; Tomasini, Richard; Vasseur, Sophie

doi:10.1073/pnas.1219555110

Public

Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma

Published in Proceedings of the National Academy of Sciences • Feb 13, 2013

Authors:

Fabienne Guillaumond

Julie Leca

O. Porta Olivares

Abstract

Pancreatic ductal adenocarcinoma is one of the most intractable and fatal cancer. The decreased blood vessel density displayed by this tumor not only favors its resistance to chemotherapy but also participates in its aggressiveness due to the consequent high degree of hypoxia. It is indeed clear tha...

Subject

Pancreatic cancer

Glycolysis

Glutamine

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