Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

Jaiswal, Siddhartha; Fontanillas, Pierre; Flannick, Jason; K. Manning, Alisa; Grauman, Peter; G. Mar, Brenton; Coleman Lindsley, R.; H. Mermel, Craig; P. Burtt, Noël; Chavez, Alejandro; M. Higgins, John; Moltchanov, Vladislav; C. Kuo, Frank; Kluk, Michael; E. Henderson, Brian; Kinnunen, Leena; A. Koistinen, Heikki; Ladenvall, Claes; Getz, Gad; Correa, Adolfo; F. Banahan, Benjamin; Gabriel, Stacey; Kathiresan, Sekar; M. Stringham, Heather; I. McCarthy, Mark; Boehnke, Michael; Tuomilehto, Jaakko; Haiman, Christopher; Groop, Leif; Atzmon, Gil; G. Wilson, James; Neuberg, Donna; Altshuler, David; L. Ebert, Benjamin

doi:10.1056/nejmoa1408617

Public

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

Published in New England Journal of Medicine • Nov 26, 2014

Authors:

Siddhartha Jaiswal

Pierre Fontanillas

Jason Flannick

Abstract

BACKGROUND: The incidence of hematologic cancers increases with age. These cancers are associated with recurrent somatic mutations in specific genes. We hypothesized that such mutations would be detectable in the blood of some persons who are not known to have hematologic disorders. METHODS: We anal...

Subject

Somatic cell

Haematopoiesis

Hematologic Neoplasms

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