The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome

Scott Hansen, R.; Wijmenga, Cisca; Luo, Ping; M. Stanek, Ann; K. Canfield, Theresa; M.R. Weemaes, Corry; M. Gartler, Stanley

doi:10.1073/pnas.96.25.14412

Public

The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome

Published in Proceedings of the National Academy of Sciences • Dec 7, 1999

Authors:

R. Scott Hansen

Cisca Wijmenga

Ping Luo

Abstract

DNA methylation is an important regulator of genetic information in species ranging from bacteria to humans. DNA methylation appears to be critical for mammalian development because mice nullizygous for a targeted disruption of the DNMT1 DNA methyltransferase die at an early embryonic stage. No DNA ...

Subject

Biology

DNMT3B

Genetics

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