Akt/Protein Kinase B Modulates Macrophage Inflammatory Response to Francisella Infection and Confers a Survival Advantage in Mice

V. S. Rajaram, Murugesan; P. Ganesan, Latha; V. L. Parsa, Kishore; P. Butchar, Jonathan; S. Gunn, John; Tridandapani, Susheela

doi:10.4049/jimmunol.177.9.6317

Public

Akt/Protein Kinase B Modulates Macrophage Inflammatory Response to Francisella Infection and Confers a Survival Advantage in Mice

Published in The Journal of Immunology • Nov 1, 2006

Authors:

Murugesan V. S. Rajaram

Latha P. Ganesan

Kishore V. L. Parsa

Abstract

The Gram-negative bacterium Francisella novicida infects primarily monocytes/macrophages and is highly virulent in mice. Macrophages respond by producing inflammatory cytokines that confer immunity against the infection. However, the molecular details of host cell response to Francisella infection a...

Subject

Protein kinase B

Proinflammatory cytokine

Biology

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